|
KMID : 0895820090190020027
|
|
Journal of Oriental Rehabilitation Medicine
2009 Volume.19 No. 2 p.27 ~ p.49
|
|
|
Effects of Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang) and Cervi Cornu Parvum Pharmaco-Acupuncture on the Motor Function Recovery and Nerve Regeneration in Rats Induced Spinal Cord Injury
|
|
Park Ji-Yong
Sul Jae-Uk
Kim Sun-Jong
Choi Jin-Bong
Shin Mi-Suk
|
|
|
Abstract
|
|
|
Objectives:
The purpose ofthisstudywasto investigate the effectsofYanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang)and CerviCornu Parvum pharmaco-acupunctureinSpinalCordInjury(SCI)-inducedrats.
Methods:
The subjectswere divided into 5 groups ;Normal,Controlno treatmentafterSCI,ExperimentalⅠ taken with Yanghyuljanggeungunbo-tang (Yangxuezhuangjinjianbu-tang)500㎎/㎏ 0.5㎖ dailyafterinducingSCI.ExperimentalⅡ takenwithCerviCornuParvum pharmaco-acupunctureat Taegye(KI3)andYangnungch?n(GB34)afterinducingSCIandExperimentalⅢ takenwithYanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang)500
㎎/㎏ 0.5㎖ andCerviCornuParvumpharmaco-acupunctureatKI3andGB34toSCI-inducedrats.Aftereachoperation,thepresentauthorobserved themotorbehaviorrecoveryandnerveregenerationbyanalysisofthemotorbehaviortests,EMG,hematological(AST,ALT,WBC),histologicaland immunologicalchanges.RatsweretestedatmodifiedTarlovtestatthe1st,2nd,3rd,4thday,andMotorbehaviortestat1st,3rd,7th,14th,21stday.
Results:
Resultsareasfollows.
1.AlltheexperimentalgroupswereimprovedcomparedwithcontrolgroupinthemotorbehaviortestsincludingTarlovtest,Basso-Beattle-Bresnahan locomotorratingscale,modifiedinclinedplanetest,openfieldtest,gridwalktestandnarrowbeam test.EspeciallyExperimentalⅢ wasimproved significantlyamongothergroups.
2.InEMGtest,HwaveappearedweakonlyinExperimentalⅢ.AndMwavewasincreasedsignificantlyinExperimentalⅢ.
3.AlltheexperimentalgroupsweresignificantlydecreasedcomparedwithcontrolgroupinserumAST,serumALTandserum WBCtests.
4.significantlydecreasedinTumorNecrosisFactor-α testcomparedwiththefirstdayofSCI.
5.Musclecontractionanddenaturationofalltheexperimentalgroupswereinhibitedinhistologicalobservationsofgastrocnemiusmuscle.Especially,those ofexperimentalⅢ wasmore effective. 6.NGFandBDNFofspinalcordgraymatterinalltheexperimentalgroupswereincreasedcomparedwithcontrolgroup.Especially,those of experimentalⅢ wasmoreeffective.
Conclusions:
Asabove,itcanbesuggestedthatYanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang)andCerviCornuParvum pharmaco-acupuncturemay improvemotorbehavior,EMG,hematological,histologicalandimmunologicalfindingsinSpinalCordInjury(SCI)-inducedrats.Especially,effectswillbe
somewhatbetterincombinationofthesetwotreatments.
|
|
|
KEYWORD
|
|
|
Spinalcordinjury, Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang), CerviCornu Parvum Pharmaco-acupuncture, Motor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|